Sydney Sweeney became a brand ambassador for Tory Burch in May 2022, reflecting shared values of empowerment and philanthropy. The brand's founder expressed admiration for Sydney's talent, curiosity, and confidence, highlighting the excitement of their collaboration.

Sydney Sweeney announced a long-term, global partnership with HEYDUDE in August 2024, focusing on promoting comfort and confidence through brand campaigns that embody the 'Dude' lifestyle.

Sydney Sweeney collaborated with Baskin-Robbins to launch the 'Sweet on Sydney Menu' in June 2025, featuring her signature ice cream creations, including 'Sydney’s Signature Scoop' and 'Sydney’s Signature Fizz.'

Sydney Sweeney is the Global Brand Ambassador for Kérastase, an international icon of modern femininity, starting in January 2024 and involved in campaigns promoting creativity and empowerment in haircare.

Sydney Sweeney joined Laneige as their first-ever global brand ambassador in January 2024, after serving as their U.S. ambassador since spring 2022. She will star in a series of new skincare campaigns for the internationally acclaimed K-beauty brand.

Sydney Sweeney is headlining American Eagle's Fall '25 campaign titled 'Sydney Sweeney Has Great Jeans,' which honors the brand's denim heritage and celebrates essential denim dressing. The campaign showcases various denim styles and aims to make customers look and feel good in AE Jeans.