Paul Mescal was revealed as a brand ambassador for Cartier's Trinity collection in February 2024, joining other ambassadors in celebrating the 100th anniversary of the Trinity line with various campaigns and events.

Paul Mescal collaborated with Samsung on the 'Samsung Spotlight' initiative in December 2020. This program supports young performing artists affected by the pandemic, and Paul Mescal starred in the launch film, showcasing a contemporary dance routine shot on the Samsung Galaxy S20.

Paul Mescal starred in a new campaign for Gucci commemorating the 70th anniversary of the classic Horsebit 1953 loafer. The campaign showcased the timeless appeal of this iconic footwear alongside Xiao Zhan.

Paul Mescal appeared in a commercial for Denny at the beginning of his career, which provided him with financial support during his initial years as an actor.