LaMelo Ball signed with Puma in October 2020, becoming a key figure in their basketball division. He has since released multiple signature sneakers, including the MB.01, MB.02, MB.03, and MB.04 models. In April 2024, Puma and LaMelo Ball launched the LaFrancé lifestyle shoe, inspired by his personal brand, and featured him in their first global basketball brand campaign titled 'FOREVER. FASTER. – See The Game Like We Do.'

LaMelo Ball partnered with DRNX in April 2022 to launch his signature Kiwi Strawberry flavor of adaptogenic water. This collaboration aims to provide athletes with a natural alternative to traditional sports drinks, emphasizing hydration and performance enhancement for active individuals. The new flavor reflects a growing trend towards healthier beverage options in the sports industry.