Alek Wek was featured in the Valentine's Day 2021 campaign for Savage X Fenty, modeling several themed ensembles from the collection, with prices ranging from $12.95 to $79.95. The shoot included notable figures like Miguel and Nazanin Mandi, and was photographed by Dennis Leupold.

Alek Wek stars in Betsey Johnson’s spring 2025 campaign, marking a joyful reunion nearly 30 years after her iconic wig toss during the designer’s fall 1998 show.

Alek Wek has developed a colorful new capsule collection with Weekend Max Mara, featuring tailored coats, sleeveless shearling vests, draped dresses, jumpsuits, and high-rise flared jeans, reflecting her African roots and cosmopolitan lifestyle.

Alek Wek fronts the SS24 campaign for & Other Stories, encouraging women to embrace challenges and personal growth. The campaign, titled 'Create your unexpected,' highlights a collection characterized by clean lines, textured silhouettes, and bold designs.

Alek Wek was appointed as the official ambassador for H&M Foundation in April 2014, collaborating to address global development issues such as education, clean water, and women's empowerment.